Diagnostic accuracy of Xpert MTB/RIF for Mycobacterium tuberculosis in pediatric bronchial lavage fluid: a meta-analysis

Review question / Objective: This study aimed to investigate further the accuracy of Xpert MTB/RIF for diagnosing Mycobacterium tuberculosis in pediatric bronchial lavage fluid.Eligibility criteria: Inclusion criteria:(1) the study type was a retrospective study.(2) the language of the literature was limited to Chinese and English.(3) the country, gender, race and course of the patients' disease in the literature were not limited.(4) the diagnostic method of the observation group was Xpert MTB/RIF.The reference tests used were M. tuberculosis cultures (tuberculosis culture based on solid or liquid media) or the composite reference standard (PTB was defined as a positive culture or clinically diagnosed based on the clinical symptoms of the patients, including cough for more than two weeks, fever, or weight loss, pneumonia that did not improve using antibiotics, or contact with an adult who had tuberculosis).(5)Children with suspected pulmonary tuberculosis.(6)the available data were used for calculating the sensitivity, specificity, and likelihood ratios.Exclusion Criteria:(1)Repeated published literature in which the original text was not found.(2) Review category, experience summary, animal experiment, case report, meeting, meta-analysis, etc. (3) Disease diagnosis is not consistent with tuberculosis in children.(4) Studies without a control group.