Penicillin Binding Proteins and β-Lactamases of Mycobacterium tuberculosis: Reexamination of the Historical Paradigm
Gaurav Kumar, Christos Galanis, Hunter R. Batchelder, Craig A. Townsend, Gyanu Lamichhane
mSphere · 2022-02
Abstract
M. tuberculosis, the causative agent of tuberculosis, kills more humans than any other bacterium. β-lactams are the most widely used class of antibiotics to treat bacterial infections. Unlike in the historical model that describes the relationship between β-lactams and M. tuberculosis, we find that M. tuberculosis penicillin binding proteins are able to inactivate select β-lactams with high efficiency.
MeSH terms
- Penicillin binding proteins
- Mycobacterium tuberculosis
- Peptidoglycan
- Tuberculosis
- Microbiology
- Antibiotics
- Penicillin
- Biology
- Cephalosporin
- Bacterial cell structure
- Bacteria
- Enzyme