Remote results of treatment in patients with pulmonary tuberculosis and previous ineffective therapy

Until recently, bedaquiline and linezolid were relatively unavailable in antituberculosis dispensaries. Patients that needed these drugs were directed to specialized Federal antituberculosis institutions. The study was aimed to evaluate remote results of the treatment of patients with drug-resistant pulmonary tuberculosis who had previous ineffective therapy at a local antituberculosis dispensary and directed to specialized Federal antituberculosis institutions. A total of 143 patients of both sexes aged 20-60 years old were examined. These patients received therapy at the Tver Regional Clinical Antituberculosis Dispensary in 2010-2014. To increase adherence to the treatment, a complex of measures were taken that included an individual session with a specialist, organization of communication with other patients that received effective therapy for tuberculosis, and watching of an educational video. A complex of measures on an increase in the adherence to the treatment among patients with pulmonary tuberculosis provided positive results in 143 patients. These patients agreed to possible surgical intervention in the Federal Antituberculosis Institution. After the surgical treatment, cavity closure and/or abacillation were registered in 132 patients. Adherence to the consumption of antituberculosis drugs significantly increased in the studied patients.