Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis
Joshua M. Thiede, Nicholas Dillon, Michael D. Howe, Ranee Aflakpui, Samuel J. Modlin, Sven Hoffner, Faramarz Valafar, Yusuke Minato, et al. (9 authors)
mBio · 2022-02
Abstract
or exposure of bacilli to drugs that target the cell wall was found to potently drive pyrazinamide susceptibility independent of environmental pH. These findings force a paradigm shift in our understanding of pyrazinamide action and open new avenues for improving diagnostic and therapeutic tools for tuberculosis.
MeSH terms
- Mycobacterium tuberculosis
- Pyrazinamide
- Cell envelope
- Tuberculosis
- Microbiology
- Envelope (radar)
- Chemistry
- Biology