Evolution of the destructive tuberculosis in children

The aim of the study was to evaluate the outcome of pulmonary tuberculosis with lung destruction in children. Material and methods: a retrospective, selective, analytical research was performed, which included 43 children with tuberculosis. Results: the most frequently affected were girls 25 (58.1%) and the age group between 15 and 18 years 34 (79.1%) cases.. Every second child was in tuberculous contact, 41.9% were actively detected and passively 22 (52.4%) cases, even if all patients were symptomatic. Infiltrative tuberculosis predominated, in equally proportion was extended and limited, in most patients with unilateral localization, and with dissemination. Microscopic positive were 20 (46.5%) cases, GeneXpert MTB / Rif positive 30 (69.8%) cases, including resistant in 9 (20.9%) cases. Therapeutic success was registered in 30 (69.8%) cases, 2 (4.7%) cases were lost to follow-up, continued treatment with TB RR/MDR 11 (25.6%) children. Conclusions: destructive pulmonary tuberculosis evolves with unsatisfactory therapeutic results, due to the association with epidemiological risk factors, passive detection, extensive localization and bronchogenic dissemination.