The Gene and Regulatory Network Involved in Ethambutol Resistance in <i>Mycobacterium tuberculosis</i>
Boni FG, Hamdi I, Moukendza Koundi L, Dai Y, Shrestra K, Abokadoum MA, Ekomi Moure UA, Suleiman IM, et al. (9 authors)
Microbial drug resistance (Larchmont, N.Y.) · 2022-08
Abstract
Ethambutol (EMB) is used in combination with isoniazid and rifampicin for the treatment of tuberculosis caused by Mycobacterium tuberculosis . However, the incidence of EMB resistance is alarming. The EMB targets the cell wall arabinan biosynthesis. It is important to comprehensively understand the molecular basis of EMB to slow down the drug resistance rate of EMB. This study summarized the genes implicated in EMB resistance, regulatory network and the pharmacoproteomic effect of EMB in M. tuberculosis . Many of the genes related to EMB are implicated in membrane components, drug efflux, lipid metabolism, ribosome, and detoxification. The differential response model may help to design a novel anti-tuberculosis antibiotic.
MeSH terms
- Humans
- Mycobacterium tuberculosis
- Tuberculosis
- Ethambutol
- Antitubercular Agents
- Microbial Sensitivity Tests
- Drug Resistance, Bacterial