Influence of the systemic inflammatory response on the state of homeostasis of the body and its reactivity in patients with respiratory tuberculosis against the «background» of chronic obstructive pulmonary disease

The aim of the study was to study the effect of the systemic inflammatory response on the body’s homeostasis and its reactivity in patients with respiratory tuberculosis against the background of chronic obstructive pulmonary disease. The study included 90 patients with respiratory tuberculosis with chronic tobacco intoxication and a history of COPD. COPD characterized by varying degrees of impaired airway patency, decreased FEV1 (p< 0.001): COPD I - 58 people (64.4%), COPD II - in 28 people (31.1%), COPD III - in 4 people (4 %). The exclusion criteria from the study were the presence of HIV infection, extra pulmonary pathology in the acute stage, metabolic syndrome, and exogenous intoxication, grade 4 COPD, with reconstructive changes in the lung tissue, previous acute myocardial infarction. The study used the data of the mandatory diagnostic minimum, assessed the biochemical parameters of systemic inflammation, lipid profile, adaptive reactions of the body, homeostatic balance of the body and its reactivity. The procedure for processing the research results was traditional with the use of electronic computers SAS 9.4. The comorbid state characterized by the presence of a systemic inflammatory response, with disorganization of protein metabolism, an increased content of CRP, a change in information redundancy and entropy of protein fractions of blood, and dyslipidemia. Systemic inflammation influenced the state of adaptive reactions, with a high significant predominance of stressed types of AR, deep and pronounced disturbance of the homeostatic balance of the body (p = 0.008) and its pathological reactivity. Thus, patients with a comorbid state characterized by pronounced systemic inflammation and deep disturbance of the adaptive reactions of the body, which largely affects the state of homeostasis and reactivity of the body, determines the course and further outcome of diseases.