Comparative Efficacy of the Novel Diarylquinoline TBAJ-876 and Bedaquiline against a Resistant <i>Rv0678</i> Mutant in a Mouse Model of Tuberculosis
Deepak Almeida, Paul J. Converse, Si-Yang Li, Anna M. Upton, Nader Fotouhi, Eric L. Nuermberger
Antimicrobial Agents and Chemotherapy · 2021-09
Abstract
Bedaquiline (BDQ, B) is the first-in-class diarylquinoline to be approved for treatment of tuberculosis (TB). Recent guidelines recommend its use in treatment of multidrug- and extensively drug-resistant tuberculosis (MDR/XDR-TB).
MeSH terms
- Bedaquiline
- Tuberculosis
- Medicine
- Mutant
- Mycobacterium tuberculosis
- Virology
- Mutation
- Microbiology
- Biology
- Drug resistance