Crosstalk between the ancestral type VII secretion system ESX-4 and other T7SS in Mycobacterium marinum
Yuchen Wang, Yuting Tang, Chen Lin, Junli Zhang, Juntao Mai, Jun Jiang, Xiaoxiao Gao, Yao Li, et al. (11 authors)
iScience · 2021-12
Abstract
mutant was more efficient in inducing actin cytoskeleton rearrangement, which led to enhanced phagocytosis by macrophages. Our results reveal an intimate crosstalk between the progenitor of T7SS and its more recent duplication and expansion, and provide new insight into the evolution of T7SS in mycobacteria.
MeSH terms
- Mycobacterium marinum
- Secretion
- ESAT-6
- Cell biology
- Crosstalk
- Biology
- Microbiology
- Mutant
- Phagocytosis
- Mycobacterium tuberculosis
- Mycobacterium