The effect of tobacco smoking on bronchial patency in patients with pulmonary tuberculosis

study about associated with tobacco smoking characteristics of respiratory function disorders in patient with tuberculesis. 87 patients with newly diagnosed infiltrative pulmonary tuberculosis (PT) were included in the study: 35 active smokers (group of smokers), and 52 never-smokers (group of non-smokers). A spirometric study with the determination of the respiratory function parameters (FEV1%, FVC% and PEF%) at the admission to the hospital, and at 1, 2 and 3 months of treatment. were considered. <b>Results:</b> The medians of the baseline values of FEV1% and FVC% (87.2% and 94.6%, respectively) in smokers were statistically significantly reduced compared to the non-smokers group (106.3% and 102.3%, respectively), being below 80% in 32% patients of the smokers group and in 6% patients in the non-smokers group. The relative risk of broncho-obstructive disorders (BOS) in smoking patients was 4.58, attributable risk, 25%. In the group of smokers the FEV1% in the course of treatment increased, reaching the maximum value at 2 months. In the smokers group a 7-fold higher growth rate for the FEV1 trend (coefficient k) was observed compared to the nonsmokers (4.72 and 0.67, respectively), which indicates to a hidden BOS in the smokers group and its normalization during treatment. In both groups, positive trends of increase in PEF% were observed, 2.6 times higher in the smokers vs. nonsmokers group (coefficient k = 6.22 and 2.4, respectively). In the smokers group, the median PEF% at the 3 months of treatment increased in 50%. The data obtained suggest, that tobacco smoking is a significant factor leading to impaired bronchial patency in patients with the pulmonary tuberculosis (PT)