The gut microbiota state in patients with pulmonary tuberculosis

<b>Aim:</b> The study of gut microbiota state in patients with pulmonary tuberculosis before and during the anti-tuberculosis treatment. <b>Materials and method:</b> 107 patients with pulmonary tuberculosis (TB) were included in the study (49 men and 58 women). The age of TB patients ranged from 20 to 60 years old. The microbiological method was performed to determine a number of normal, conditionally pathogenic and pathogenic bacteria in the feces. The data were obtained at the admission, after 1 week and 1 month&nbsp;of anti-TB treatment. <b>Results:</b> It was found that before beginning the treatment, the majority of TB patients had a decreased number of bifidobacteria (89,7%), lactobacilli (74,7%) and typical E.coli (55,1%). The mean values of these markers were significantly lower than reference values. After 1 week of anti-TB treatment, 94,4%, 79,4% and 55,1% of TB patients had the decreased level of bifidobacteria, lactobacilli and typical E. coli, during 1 month of anti-TB treatment – 89,7%, 77,5% and 64,4%, respectively. Decreased level of enterococci before treatment was observed in 17,0% of TB patients. During anti-TB treatment, the number of such TB patients increased and after 1 week it was 25,2%, and after 1 month – 32,4%. The mean value of this marker before the beginning and during treatment was significantly lower than reference values. The frequency of occurrence of an increased number of Candida before treatment was 15,0%, after 1 week of treatment – 17,0%,&nbsp;after 1 month of treatment – 37,4%. <b>Conclusion:</b> In TB patients primary state of gut microbiota was differed from normal. During anti-TB treatment changes in gut microbiota increased.