Lessons Learned from Implementation of an Interferon Gamma Release Assay to Screen for Latent Tuberculosis Infection in a Large Multicenter Observational Cohort Study in Brazil
Allyson G. Costa, Brenda K. S. Carvalho, Mariana Araújo-Pereira, Hiochelson N. S. Ibiapina, Renata Spener-Gomes, Alexandra B. Souza, Adriano Gomes-Silva, Alice M. S. Andrade, et al. (23 authors)
Microbiology Spectrum · 2021-12
Abstract
The IGRA has emerged as a useful tool for identifying persons with LTBI. Although the implementation of IGRAs is of utmost importance, to our knowledge there is scarce information on the identification of logistical and technical challenges for systematic screening for LTBI on a large scale. Thus, the descriptions of the problems identified and resolved in this study can assist laboratories implementing IGRAs, in addition to manufacturers of IGRAs providing effective technical support. This will facilitate the implementation of IGRA testing in countries with large TB burdens, such as Brazil.
MeSH terms
- Tuberculosis
- Medicine
- Latent tuberculosis
- Tuberculin
- Observational study
- Cohort study
- Interferon gamma release assay
- Cohort
- Test (biology)
- Interferon γ
- Comparative effectiveness research
- Protocol (science)
- Gold standard (test)
- Health care
- Intensive care medicine
- Diagnostic test
- Prospective cohort study
- Tuberculosis diagnosis
- Family medicine
- Medical physics
- Tuberculin test