Effectiveness of complex treatment of bilateral destructive pulmonary XDR-tuberculosis

<b>Objective:</b> to evaluate the effectiveness of treatment of destructive pulmonary XDR-tuberculosis with the use of chemotherapy, collapsetherapy and endobronchial valve installation. <b>Methods:</b> a retrospective study. From 2016 to 2020, 125 patients with XDR-tuberculosis were treated at the Central Research Institute. Patients were divided into 2 groups, the 1st group consisted of 65 patients with lung destruction and bacterial excretion, who received chemotherapy with Bedaquiline, and also received collapsetherapy in the form of pneumoperitoneum and endobronchial valve (EV) installation. Group 2 included 60 patients who received bedaquiline, without collapse therapy and EV. All patients received basic TB therapy for 24 months. A comparison was made between the closure of decay cavities and sputum denial in patients of groups 1 and 2 at 6 and 12 months. <b>Results:</b> in group 1, 27 patients (41.5%) had carious cavities closed by 6 months of treatment. In group 2 patients, the caverns were closed in 16 cases (26.6%). By 12 months of treatment in the first group, the caverns were closed in 49 patients (75.3%), in group 2-in 32 patients (53.3%)(P1-2&lt;0.05). Negativation of sputum in group 1 after 6 months was observed in 61 patients (93.8%),&nbsp;in group 2, negativity was observed in 48 cases (80%). After 12 months in the first group, negation of the sputum was observed in 65 patients (100%), in the second group, 53 patients (88,3%)(P1-2&lt;0,05). <b>Conclusions:</b> in the treatment of XDR TB with the use of chemotherapy, collapsotherapy and install EV have a larger number of patients is closure of the cavity and quick to negative sputum.