Detecting <i>Mycobacterium Tuberculosis</i> using a nitrofuranyl calanolide–trehalose probe based on nitroreductase Rv2466c
Xueyuan Li, Pengfei Geng, Xiao-Qiao Hong, Zhaogang Sun, Gang Liu
Chemical Communications · 2021-01
Abstract
a unique fluorescence off-on feature by a Rv2466c-mediated reductive mechanism. This probe effectively facilitates the rapid and specific detection of Mtb in the host cell during infection and the detection of Mtb in sputum samples from patients.
MeSH terms
- Nitroreductase
- Mycobacterium tuberculosis
- Trehalose
- Sputum
- Tuberculosis
- Microbiology
- Fluorescence
- Chemistry
- Biology