Functionalized Dioxonaphthoimidazoliums: A Redox Cycling Chemotype with Potent Bactericidal Activities against <i>Mycobacterium tuberculosis</i>
Kevin Timothy Fridianto, Ming Li, Kiel Hards, Dereje A. Negatu, Gregory M. Cook, Thomas Dick, Yulin Lam, Mei‐Lin Go
Journal of Medicinal Chemistry · 2021-10
Abstract
revealed good activity against nutrient-starved organisms in the Loebel model of dormancy, low spontaneous resistance mutation frequency, and synergy with isoniazid in the checkerboard assay.
MeSH terms
- Chemistry
- Redox
- Biochemistry
- Lipophilicity
- Mycobacterium tuberculosis
- Reactive oxygen species
- Quinone
- Efflux
- Microbiology
- Isoniazid
- Bacteria