Role of Epistasis in Amikacin, Kanamycin, Bedaquiline, and Clofazimine Resistance in Mycobacterium tuberculosis Complex
Roger Vargas, Luca Freschi, Andrea Spitaleri, Sabira Tahseen, Ivan Barilar, Stefan Niemann, Paolo Miotto, Daniela María Cirillo, et al. (10 authors)
Antimicrobial Agents and Chemotherapy · 2021-08
Abstract
Antibiotic resistance among bacterial pathogens poses a major global health threat. Mycobacterium tuberculosis complex (MTBC) is estimated to have the highest resistance rates of any pathogen globally. Given the low growth rate and the need for a biosafety level 3 laboratory, the only realistic avenue to scale up drug susceptibility testing (DST) for this pathogen is to rely on genotypic techniques.
MeSH terms
- Bedaquiline
- Clofazimine
- Amikacin
- Mycobacterium tuberculosis
- Microbiology
- Mycobacterium tuberculosis complex
- Kanamycin
- Tuberculosis
- Biology
- Pathogen
- Drug resistance
- Virology
- Antibiotics