Model-Based Exposure-Response Assessment for Spectinamide 1810 in a Mouse Model of Tuberculosis
Santosh Wagh, Chetan Rathi, Pradeep B. Lukka, Keyur Parmar, Zaid H. Temrikar, Jiuyu Liu, Michaël Scherman, Richard Lee, et al. (11 authors)
Antimicrobial Agents and Chemotherapy · 2021-08
Abstract
Despite decades of research, tuberculosis remains a leading cause of death from a single infectious agent. Spectinamides are a promising novel class of antituberculosis agents, and the lead spectinamide 1810 has demonstrated excellent efficacy, safety, and drug-like properties in numerous in vitro and in vivo assessments in mouse models of tuberculosis.
MeSH terms
- In vivo
- Pharmacodynamics
- Pharmacology
- Pharmacokinetics
- Tuberculosis
- Minimum inhibitory concentration
- Mycobacterium tuberculosis
- Dosing
- Population
- Medicine
- Drug
- In vitro
- Area under the curve
- Immunology
- Microbiology