Exploring the eligibility of all reported lipoarabinomannan-testing assays in different clinical situations: A systematic review and meta-analysis of 97 articles

Review question / Objective: This work summarized all reported LAM-testing assays, collected all data about the diagnostic capacity of these assays, scientifically pooled data and compared the performance of these different assays in the same situations. This work aimed to identify the application scopes of all reported LAM-testing assays and then offer guidance for clinicians to make correct medical decision in different clinical situations. Information sources: A search in 3 databases (PubMed, Embase, and Web of Science) with a series of subject headings [(tuberculosis OR TB) AND (lipoarabinomannan OR LAM)] up to August 23, 2020 was conducted. Bibliographies of relevant researches and a forward search were also manually assessed. Language restriction was set at English.