Role of Premycofactocin Synthase in Growth, Microaerophilic Adaptation, and Metabolism of Mycobacterium tuberculosis
Krishnamoorthy Gopinath, Peggy Kaiser, Patricia Constant, Ulrike Abu Abed, Monika Schmid, Christian K. Frese, Volker Brinkmann, Mamadou Daffé, et al. (9 authors)
mBio · 2021-07
Abstract
Characterization of proteins with unknown functions is a critical research priority as the intracellular growth and metabolic state of Mycobacterium tuberculosis , the causative agent of tuberculosis, remain poorly understood. Mycofactocin is a peptide-derived redox cofactor present in almost all mycobacterial species; however, its functional relevance in M. tuberculosis pathogenesis and host survival has never been studied experimentally.
MeSH terms
- Mycobacterium smegmatis
- Biology
- Biochemistry
- Mycobacterium tuberculosis
- Mutant
- Biosynthesis
- Metabolism
- Cofactor
- Enzyme
- Gene