Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzyme
Katharigatta N. Venugopala, Sandeep Chandrashekharappa, Pran Kishore Deb, Christophe Tratrat, Melendhran Pillay, Deepak Chopra, Nizar A. Al‐Shar’i, Wafa Hourani, et al. (22 authors)
Journal of Enzyme Inhibition and Medicinal Chemistry · 2021-01
Abstract
) demonstrated no toxicity for these compounds. Thus, the indolizines warrant further development and may represent a novel promising class of InhA inhibitors and multi-targeting agents to combat drug-sensitive and drug-resistant MTB strains.
MeSH terms
- INHA
- In silico
- Chemistry
- Docking (animal)
- Mycobacterium tuberculosis
- Enzyme
- In vitro
- Reductase
- Isoniazid
- Stereochemistry
- Biochemistry
- Pharmacology