Particularities of immunological reactivity, nitric oxide and its metabolities production in patients with pulmonary tuberculosis in association with covid-19 infection

The study included 24 patients, which formed the baseline group — 12 patients with pulmonary tuberculosis in combination with COVID-19 infection and the control group — 12 patients with pulmonary tuberculosis. There were studied the leukocyte formula, the content of CD3, CD4, CD8 lymphocytes, the content of NO2-+NO3- total and its metabolites. The obtained results showed that in patients with pulmonary tuberculosis and COVID-19 there is a pronounced decrease of lymphocytes and an unexpressed shift of the leukocyte formula to the left. The lymphocyte content decreases due to CD3 lymphocytes and their subpopulation of CD4 (helper) lymphocytes. The CD4/CD8 immunoregulatory index demonstrates a stimulation of immunological reactivity in patients with pulmonary tuberculosis and depression of immunological reactivity in patients with pulmonary tuberculosis in combination with COVID-19 infection and a pronounced suppression of the production content of NO2-+NO3- total and its metabolites (NO2- and NO3-).