Xpert MTB/RIF Ultra Is Highly Sensitive for the Diagnosis of Tuberculosis Lymphadenitis in a High-HIV Setting
Stephanie Minnies, Byron W. P. Reeve, Loren Rockman, Georgina Nyawo, Charissa C. Naidoo, Natasha Kitchin, Cornelia Rautenbach, Colleen A. Wright, et al. (12 authors)
Journal of Clinical Microbiology · 2021-09
Abstract
Tuberculosis lymphadenitis (TBL) is the most common extrapulmonary tuberculosis (EPTB) manifestation. Xpert MTB/RIF Ultra (Ultra) is a World Health Organization-endorsed diagnostic test, but performance data for TBL, including on noninvasive specimens, are limited. Fine-needle aspiration biopsy specimens (FNABs) from outpatients (≥18 years) with presumptive TBL ( n = 135) underwent (i) routine Xpert MTB/RIF testing (later with Ultra once programmatically available), (ii) an MGIT 960 culture (if Xpert or Ultra negative or rifampin resistant), and (iii) study Ultra testing. Concentrated paired urine specimens underwent Ultra testing.
MeSH terms
- Medicine
- Tuberculosis
- False positive paradox
- Mycobacterium tuberculosis
- Rifampicin
- Tuberculosis diagnosis
- Internal medicine
- Urine
- Biopsy
- Extrapulmonary tuberculosis
- Diagnostic test
- Fine-needle aspiration
- Gold standard (test)
- Concordance
- Pathology
- Confidence interval