Association between Nitric Oxide (Sputum Induction and Asthma Control Level on Asthma Outpatients

Background: Asthma is a heterogeneous disease with chronic inflammatory characteristics of the respiratorytract. (Nitric Oxide) (NO) levels increased significantly in patients with inflammation such as asthma in thisstudy. Nitric Oxide (NO) levels in normal people and asthma patients are different, but no sputum of NitricOxide (NO) levels are associated with asthma control levels.Method: Thirty-patients consecutive sampling was conducted at asthma unit Dr. Soetomo Teaching HospitalSurabaya. The subjects were met the inclusion and exclusion criteria that assessed their asthma control withasthma control test (ACT) then measured by NO levels.Results: In this study, the subjects were divided into asthma control level; full-controlled was 4 subjects(13,3%), partially-controlled was 8 subjects (26,7%), and uncontrolled was 18 subjects (60,0%). The meanasthma control level was 18.3±4.2 with the lowest Asthma control test (ACT) score was 8 and the highestACT score was 25. The mean NO sputum induction level was 92.043±29.040 ?M, with the lowest NOwas 14.566 ?M and the highest NO was 138.350 ?M. The result of the statistical test showed a negativecorrelation significantly between NO-induced sputum level and asthma control level (p <0,05).Conclusion: The examination of NO sputum level could be used as an indicator in determining the level ofasthma control.