Single-nucleotide polymorphism rs2070600 regulates<i>AGER</i>splicing and the sputum levels of the COPD biomarker soluble receptor for advanced glycation end-products
Alen Faiz, Senani N. H. Rathnayake, Nick H.T. ten Hacken, Victor Guryev, Maarten van den Berge, Simon D. Pouwels
ERJ Open Research · 2021-04
Abstract
<b>The COPD susceptibility SNP rs2070600 affects the levels of the COPD biomarker sRAGE in sputum as well as splicing of <i>AGER</i>. Moreover, @PouwelsScience <i>et al.</i> demonstrate large differences in sRAGE levels between serum and sputum.</b>https://bit.ly/3t0pJtK
MeSH terms
- Single-nucleotide polymorphism
- Biomarker
- Sputum
- Medicine
- COPD
- Glycation
- SNP
- RNA splicing
- Receptor
- Cancer research
- Genotype
- Internal medicine