N-Thio-β-lactams targeting L,D-transpeptidase-2, with activity against drug-resistant strains of Mycobacterium tuberculosis
Giulia Martelli, Tomás Bohn Pessatti, Eva Maria Steiner, Martina Cirillo, Caso Carolina, Francesco Bisognin, Michael Landreh, Paola Dal Monte, et al. (10 authors)
Cell chemical biology · 2021-04
Abstract
. The resulting stable adducts lead to a long-term inactivation of the target protein. Finally, the candidates were evaluated in vitro against a drug-susceptible and multidrug-resistant clinical isolates of M. tuberculosis, confirming the antimycobacterial effect of these novel compounds.
MeSH terms
- Mycobacterium tuberculosis
- Tuberculosis
- Antimycobacterial
- Chemistry
- Thio-
- Microbiology
- Ligand (biochemistry)
- Antimicrobial
- Drug resistance
- Lactam
- Ligand efficiency
- Combinatorial chemistry
- Biology