Characteristics, and predictive factors of disease severity in hospitalized patients with SARS-COV-2 in Fayoum governorate, Egypt: a multicenter study

Background: SARS-COV-2 pandemic is a serious health problem all over the world including Egypt, thus realizing the predictive factors and disease’s characteristics is an essential issue.Objectives: To evaluate the characteristics of laboratory-confirmed cases of SARS-CoV-2 infection in Fayoum governorate, Egypt, and to determine the predictive factors of disease severity.Methods: 140 patients confirmed with SARS-CoV-2 from the Fayoum governorate, Egypt, were collected in this descriptive multicenter study. The subtype classification of COVID-19 was according to the WHO guideline COVID-19 disease severity classification. Patients were divided into a asymptomatic/non-severe cases group and a severe/critical case group. Each patient was subjected to chest computed tomography (CT), clinical, and laboratory assessment in form of complete blood count, neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), liver function tests, urea, creatinine, C‐reactive protein (CRP), serum ferritin, and D- dimer. Results: Severe/critical patients were older (52.0±12.6) with a statistical significantly higher rate of diabetic mellitus, hypertension, and tuberculosis (TB) (p < /p>