Developing Synergistic Drug Combinations To Restore Antibiotic Sensitivity in Drug-Resistant Mycobacterium tuberculosis
Charles Omollo, Vinayak Singh, Elizabeth Kigondu, Antonina Wasuna, Pooja Agarwal, Atica Moosa, Thomas R. Ioerger, Valerie Mizrahi, et al. (10 authors)
Antimicrobial Agents and Chemotherapy · 2021-02
Abstract
Tuberculosis (TB) is a leading global cause of mortality owing to an infectious agent, accounting for almost one-third of antimicrobial resistance (AMR) deaths annually. We aimed to identify synergistic anti-TB drug combinations with the capacity to restore therapeutic efficacy against drug-resistant mutants of the causative agent, Mycobacterium tuberculosis .
MeSH terms
- Mycobacterium tuberculosis
- Rifampicin
- Isoniazid
- Tuberculosis
- Drug resistance
- Microbiology
- Biology
- Antibiotics
- Pharmacology