Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of <i>Mycobacterium tuberculosis</i> Growth
Peter C. Ray, Margaret Huggett, Penelope A. Turner, Malcolm Taylor, Laura A. T. Cleghorn, Julie V. Early, Anuradha Kumar, Shilah A. Bonnett, et al. (37 authors)
ACS Omega · 2021-01
Abstract
exposure remaining above the minimal inhibitory concentration for only a limited time.
MeSH terms
- hERG
- Mycobacterium tuberculosis
- Chemistry
- Cytotoxicity
- Biochemistry
- In vitro
- Potassium channel
- Pharmacology
- Tuberculosis