Activity of Clofazimine and TBI-166 against Mycobacterium tuberculosis in Different Administration Intervals in Mouse Tuberculosis Models
Hui Zhu, Lei Fu, Bin Wang, Xi Chen, Jiaojie Zhao, Haihong Huang, Yu Lu
Antimicrobial Agents and Chemotherapy · 2021-01
Abstract
Clofazimine (CLO) and TBI-166 belong to the riminophenazine class of antimicrobial agent. TBI-166 exhibited promising antituberculosis activity in vitro and in animal models and is currently under phase I clinical development for the treatment of tuberculosis in China.
MeSH terms
- Clofazimine
- Tuberculosis
- Mycobacterium tuberculosis
- Medicine
- Antimicrobial
- Pharmacology
- Microbiology
- Biology