Association of N-acetyltransferase 2 (NAT2) polymorphisms and elevated liver enzymes of Myanmar tuberculosis patients in Thailand
Khin Sandi Thaw, Chanchira Choppradit, Pornpimol Kijsanayotin, Ratchanee Rodsiri
The Thai Journal of Pharmaceutical Sciences · 2020-01
Abstract
Isoniazid (INH) and its toxic metabolites are the major cause of anti-tuberculosis (TB) druginduced liver injury (AT-DILI). N-acetyltransferase 2 (NAT2) is involved in many metabolic pathways of INH. Previous studies demonstrated the association of NAT2 .
MeSH terms
- Genotype
- Single-nucleotide polymorphism
- Isoniazid
- SNP
- Tuberculosis
- Biology
- Allele
- Arylamine N-acetyltransferase
- Internal medicine
- Gastroenterology
- Medicine
- Genetics