Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents
Julia Fernández de Luco, Alejandro Recio-Balsells, Diego G. Ghiano, Ana Bortolotti, Juan M. Belardinelli, Nina Liu, Pascal Hoffmann, Christian Lherbet, et al. (12 authors)
RSC Medicinal Chemistry · 2020-11
Abstract
could be considered a valuable starting point for future antileishmanial drug development. The validation of a putative leishmanial InhA orthologue as a therapeutic target needs to be further investigated.
MeSH terms
- INHA
- Triclosan
- Cytotoxicity
- Leishmania
- Chemistry
- Leishmania donovani
- Drug discovery
- Isoniazid
- Enzyme
- Leishmaniasis
- Combinatorial chemistry
- Vero cell
- Pharmacology
- Biochemistry
- Tuberculosis
- Biology