Endobronchial tuberculosis: characteristics and bronchoscopic findings in children
Ludmila Santos, Letícia Oliveira Dias, Paula Soares, Carmem Lúcia Teixeira de Castro, Robson De Alvarenga Facina, Licinio Esmeraldo Da Silva, Christiane Mello Schmidt, Claudete Aparecida Araújo Cardoso, et al. (9 authors)
Tuberculosis · 2020-09
Abstract
<b>Introduction:</b> Endobronchial tuberculosis (EBTB) in children can be confused with asthma or foreign body aspiration. In the adult population, Chung HS classification is used based on bronchoscopic findings, but in children a similar study has not been established. <b>Objective:</b> To evaluate the characteristics and bronchoscopic findings of EBTB in children with pulmonary TB. <b>Methods:</b> Retrospective study of EBTB in children at university hospital in the state of Rio de Janeiro, Brazil, over a 10-year period (2009-2019). EBTB was considered if there were endoscopic changes and positive sputum smear and/or culture and/or rapid molecular test for <i>Mycobacterium tuberculosis</i> in bronchial or bronchoalveolar lavage. <b>Results:</b> There were 17 cases between 0 and 18 years of age, with 59% ≤ 10 years. There was a predominance of females (59%). Suspected tuberculosis was the main indication for bronchoscopy following by maintained radiological image. In 6% of cases, the indication was suspected of a foreign body. None of the cases was suspected TBEB. The main symptom was cough. Culture was positive in 82% of cases and rapid molecular testing and smear microscopy in 12% each. Bronchoscopic findings: carina enlargement (59%), extrinsic compression (47%), mucopurulent secretion (23%), caseum (18%), granulomatous lesion (12%), mucosal edema and hyperemia (6%) and clear secretion were observed (6%). <b>Conclusions:</b> EBTB in children is still underdiagnosed. Although the small sample is a limiting factor, the variability of bronchoscopic findings suggests the need for a specific classification for the pediatric population. This may provide a better forecast of the therapeutic result of EBTB, as observed in the adult population.
MeSH terms
- Medicine
- Bronchoscopy
- Tuberculosis
- Sputum
- Bronchoalveolar lavage
- Population
- Retrospective cohort study
- Mycobacterium tuberculosis
- Radiology
- Surgery
- Internal medicine
- Gastroenterology