Preparation and evaluation of isoniazid loaded chitosan nanostructures

The objective of this investigation was fabrication and evaluation of isoniazid loaded chitosan nanostructures. Nanostructures were fabricated by ionotropic gelation technique, and evaluated by average particle size, encapsulation efficacy, drug loading, Fourier transform infrared spectroscopy and in vitro drug release. The fabricated nanostructures were having particle size, drug loading and encapsulation efficiency ranging 234.2 to 716.8 nm, 12.70% to 17.77% and 47.7% to 79.97%, respectively. The optimized nanoformulation was found to show sustained release of drug during 24 hrs study period.