Daratumumab (Anti-CD38) for Treatment of Disseminated Nontuberculous Mycobacteria in a Patient With Anti–Interferon-γ Autoantibodies
Sebastian Ochoa, Li Ding, Samantha Kreuzburg, Jennifer Treat, Steven M. Holland, Christa S. Zerbe
Clinical Infectious Diseases · 2020-08
Abstract
Patients with autoantibodies to interferon-γ (IFN-γ) may develop severe nontuberculous mycobacterial infections. We describe the novel use of daratumumab in a patient with autoantibodies to IFN-γ who had progressive infection, resulting in clinical and radiographic improvement.
MeSH terms
- Medicine
- Daratumumab
- Autoantibody
- Nontuberculous mycobacteria
- Immunology
- Interferon alfa
- Interferon
- Alpha interferon
- Dermatology