The unfoldase ClpC1 of Mycobacterium tuberculosis regulates the expression of a distinct subset of proteins having intrinsically disordered termini
Ajitesh Lunge, Radhika Gupta, Eira Choudhary, Nisheeth Agarwal
Journal of Biological Chemistry · 2020-05
Abstract
transcripts. In summary, the cellular levels of oligomeric proteins such as Hsp20 are maintained post-translationally through their recognition, disassembly, and degradation by ClpC1, which requires disordered ends in its protein substrates.
MeSH terms
- Biology
- Mycobacterium tuberculosis
- Protease
- Heat shock protein
- Gene knockdown
- Cell biology
- Gene silencing
- Protein subunit
- Proteases
- Gene