Evaluation of GeneXpert MTB/RIF as a diagnostic tool in patients with sputum smear-negative TB in a high HIV burden region in Nigeria
Abdulwasiu Bolaji Tiamiyu, Garba Iliyasu, Farouq Muhammad Dayyab, Zaiyad Garba Habib, Sirajo Haliru Tambuwal, Habibu Galadanci, Sunday Bwala, Lovett Lawson, et al. (9 authors)
Transactions of the Royal Society of Tropical Medicine and Hygiene · 2020-03
Abstract
BACKGROUND: There are challenges in the diagnosis of TB in people with smear-negative pulmonary TB (SNPTB) in resource-limited settings. We evaluated the diagnostic usefulness of Xpert MTB/RIF compared with TB culture among SNPTB. METHODS: The study was a cross-sectional study among patients with SNPTB. The Xpert MTB/RIF tests and sputum culture (using Lowenstein-Jensen medium) were performed. Sensitivity and specificity were calculated. RESULTS: Of 150 patients studied, the sensitivity and specificity of GeneXpert MTB/RIF were 81.8 and 97.4%, respectively. CONCLUSION: The sensitivity and specificity of Xpert MTB/RIF assay was comparative with culture in SNPTB patients.
MeSH terms
- GeneXpert MTB/RIF
- Medicine
- Sputum
- Tuberculosis
- Human immunodeficiency virus (HIV)
- Internal medicine
- Sputum culture
- Pulmonary tuberculosis
- Virology
- Diagnostic accuracy
- Mycobacterium tuberculosis