Cover Feature: A Concise Synthesis of Oligosaccharides Derived From Lipoarabinomannan (LAM) with Glycosyl Donors Having a Nonparticipating Group at C2 (Eur. J. Org. Chem. 14/2020)
Zhihao Li, Changping Zheng, Marco Terreni, Teodora Bavaro, Matthieu Sollogoub, Yongmin Zhang
European Journal of Organic Chemistry · 2020-04
Abstract
The Cover Feature shows kids (chemists) building blocks with monosaccharides “building blocks” through a convenient method. The key steps for stereoselective construction of glycosidic bonds by acceptors glycosylated with donors without neighboring participating group were achieved. After several steps and one step birch reaction, 5 oligosaccharides with terminal amino group at the anomeric substituent were obtained which will be used for conjugation with TB protein as potential vaccine candidates against tuberculosis. More information can be found in the Full Paper by Y. Zhang et al.
MeSH terms
- Chemistry
- Glycosidic bond
- Lipoarabinomannan
- Stereoselectivity
- Substituent
- Stereochemistry
- Monosaccharide
- Glycosyl
- Group (periodic table)
- Anomer
- Leaving group