TB Research

A pilot study: VereMTB detection kit for rapid detection of multidrug-resistant mycobcterium tuberculosis in clinical sputum samples

Xichao Ou, Qiang Li, Dan Su, Hui Xia, Shengfen Wang, Bing Zhao, Yanlin Zhao

PLoS ONE · 2020-03

Abstract

The performance of VereMTBTM Detection Kit for detection of multidrug-resistant tuberculosis (MDR-TB) was validated by using 124 sputum samples. Comparing with MGIT culture, the sensitivity and specificity of VereMTB Detection Kit for MTBC detection were 97.0% and 98.3%, respectively. Compared with MGIT DST, the sensitivity and specificity of VereMTB Detection Kit for RIF resistance detection were 85.7% and 93.9%, respectively, and the sensitivity and specificity of VereMTB Detection Kit for INH resistance detection were 75.0% and 95.7%, respectively. 6 NTM samples were also detected and identified correctly. The VereMTB Detection Kit can detect MDR-TB rapidly and accurately in sputum samples from TB suspects.

MeSH terms

  • Sputum
  • Tuberculosis
  • Multiple drug resistance
  • Medicine
  • Detection limit
  • Microbiology
  • Drug resistance