<i>N</i> -Acetyltransferase 2 Genotypes among Zulu-Speaking South Africans and Isoniazid and <i>N</i> -Acetyl-Isoniazid Pharmacokinetics during Antituberculosis Treatment
Thuli Mthiyane, James Millard, John Adamson, Yusentha Balakrishna, Cathy Connolly, Andrew Owen, Roxana Rustomjee, Keertan Dheda, et al. (10 authors)
Antimicrobial Agents and Chemotherapy · 2020-01
Abstract
The distribution of N -acetyltransferase 2 gene ( NAT2 ) polymorphisms varies considerably among different ethnic groups. Information on NAT2 single-nucleotide polymorphisms in the South African population is limited. We investigated NAT2 polymorphisms and their effect on isoniazid pharmacokinetics (PK) in Zulu black HIV-infected South Africans in Durban, South Africa. HIV-infected participants with culture-confirmed pulmonary tuberculosis (TB) were enrolled from two unrelated studies.
MeSH terms
- Isoniazid
- Pharmacokinetics
- Zulu
- Tuberculosis
- Genotype
- Arylamine N-acetyltransferase
- Population
- Medicine
- Biology
- Virology
- Pharmacology