TB Research

Linezolid-Induced Toxic Optic Neuropathy

Aljebreen MA, Alotaibi AK, Alrobaian M

Middle East African journal of ophthalmology · 2020-10

Abstract

To report a case of linezolid-induced toxic optic neuropathy. Clinical examination and imaging are presented over a 4-month interval from initial presentation to subsequent follow-up of 4 months after discontinuation of linezolid. The patient was found to have optic neuropathy as demonstrated by clinical presentation and examination. Upon discontinuation of linezolid, the patient's visual acuity, visual fields, and color vision significantly improved. Linezolid has previously been reported to cause toxic optic neuropathy and retinopathy. We hereby describe a tuberculosis patient with linezolid-associated toxic optic neuropathy. Our report aims to describe the ocular side effects of linezolid use to enhance awareness.

MeSH terms

  • Humans
  • Tuberculosis, Multidrug-Resistant
  • Anti-Bacterial Agents
  • Visual Acuity
  • Visual Fields
  • Adult
  • Male
  • Color Vision
  • Linezolid
  • Toxic Optic Neuropathy