Synthesis and evaluation of heterocycle structures as potential inhibitors of Mycobacterium tuberculosis UGM
Maaliki C, Fu J, Villaume S, Viljoen A, Raynaud C, Hammoud S, Thibonnet J, Kremer L, et al. (10 authors)
Bioorganic & medicinal chemistry · 2020-06
Abstract
In this study, we screen three heterocyclic structures as potential inhibitors of UDP-galactopyranose mutase (UGM), an enzyme involved in the biosynthesis of the cell wall of Mycobacterium tuberculosis. In order to understand the binding mode, docking simulations are performed on the best inhibitors. Their activity on Mycobacterium tuberculosis is also evaluated. This study made it possible to highlight an "oxazepino-indole" structure as a new inhibitor of UGM and of M. tuberculosis growth in vitro.
MeSH terms
- Humans
- Mycobacterium tuberculosis
- Tuberculosis
- 4-Butyrolactone
- Indoles
- Intramolecular Transferases
- Enzyme Inhibitors
- Antitubercular Agents
- Microbial Sensitivity Tests
- Drug Evaluation, Preclinical
- Molecular Structure
- Protein Binding
- Molecular Docking Simulation