Evaluation of GeneXpert MTB/RIF as a diagnostic tool in patients with sputum smear-negative TB in a high HIV burden region in Nigeria
Tiamiyu AB, Iliyasu G, Dayyab FM, Habib ZG, Tambuwal SH, Galadanci H, Bwala SA, Lawson L, et al. (9 authors)
Transactions of the Royal Society of Tropical Medicine and Hygiene · 2020-09
Abstract
Background There are challenges in the diagnosis of TB in people with smear-negative pulmonary TB (SNPTB) in resource-limited settings. We evaluated the diagnostic usefulness of Xpert MTB/RIF compared with TB culture among SNPTB. Methods The study was a cross-sectional study among patients with SNPTB. The Xpert MTB/RIF tests and sputum culture (using Lowenstein-Jensen medium) were performed. Sensitivity and specificity were calculated. Results Of 150 patients studied, the sensitivity and specificity of GeneXpert MTB/RIF were 81.8 and 97.4%, respectively. Conclusion The sensitivity and specificity of Xpert MTB/RIF assay was comparative with culture in SNPTB patients.
MeSH terms
- Sputum
- Humans
- Mycobacterium tuberculosis
- HIV Infections
- Rifampin
- Antibiotics, Antitubercular
- Sensitivity and Specificity
- Cross-Sectional Studies
- Nigeria