Elevated Matrix Metalloproteinase Concentrations Offer Novel Insight Into Their Role in Pediatric Tuberculous Meningitis
Li YJ, Wilkinson KA, Wilkinson RJ, Figaji AA, Rohlwink UK
Journal of the Pediatric Infectious Diseases Society · 2020-02
Abstract
We collected lumbar and ventricular cerebrospinal fluid and serum from 40 children treated for tuberculous meningitis and measured the concentrations of gelatinases and their inhibitors. The concentrations of matrix metalloproteinase 9 (MMP-9), MMP-2, tissue inhibitor of metalloproteinase 1 (TIMP-1), and TIMP-2 were significantly elevated in the lumbar CSF samples, and we found interesting dynamics for MMP-9 that offer novel insight into its role in pediatric patients with tuberculous meningitis.
MeSH terms
- Humans
- Tuberculosis, Meningeal
- Gelatinases
- Prognosis
- Statistics, Nonparametric
- Case-Control Studies
- Reference Values
- Adolescent
- Child
- Child, Preschool
- Infant
- Female
- Male
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
- Matrix Metalloproteinase Inhibitors