Synthesis and Biological Activity study of some New Isonicotinic Acid Hydrazide (isoniazid) Derivatives
Kareem .S. Abass, R Torschutz, A Karger, A Farah, A Alousi, J Svetlik, N Pronayova, V Hanas, et al. (53 authors)
Abstract
The work was included the synthesis of some new allyl , vinyl , tosyl and methyl derivatives for isonicotinic acid hydrazide( isoniazid ).The products were characterized by elemental analysis besides the IR and 1 H-NMR spectroscopic identifications .The work was also included the study of the biological activity of the products , starting material (isoniazid) and some antibiotics ,.This study shows that the biological activity of products is more than that of the isoniazid and the antibiotics.
MeSH terms
- Isonicotinic acid
- Hydrazide
- Isoniazid
- Chemistry
- Niacin
- Pharmacology
- Combinatorial chemistry