A case of acquired immunodeficiency syndrome combined with cryptococcal meningitis and tuberculous meningitis and related literatures review

Objective To improve the understanding of acquired immunodeficiency syndrome (AIDS) and central nervous system (CNS) combined infection of Cryptococcus neoformans and Mycobacterium tuberculosis. Methods The diagnosis and treatment of a case of AIDS combined with new cryptococcal meningitis and tuberculous meningitis were analyzed, and relevant literatures were reviewed. Results On March 17th, 2015, a 38-year-old male patient with AIDS complicated with cryptococcal meningitis was admitted to Zhongnan Hospital of Wuhan University. After complete examination, the case was diagnosed as mixed infection of Cryptococcus neoformans and Mycobacterium tuberculosis. After antiinfection and comprehensive symptomatic treatment, the condition of the case was relieved and the prognosis was relatively well. Conclusions For patients with AIDS combined with cryptococcal meningitis and tuberculous meningitis, timely diagnosis, combined treatment with anti-cryptococcus and anti-tuberculosis and initiation of antiretroviral therapy at the right moment are expected to improve the prognosis. Key words: Acquired immunodeficiency syndrome; Cryptococcal meningitis; Tuberculous meningitis