Proteomic study on different-type samples of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a severe lung disease with chronic inflammation and gradually declined pulmonary function.Its incidence rate has been rising with poor prognosis, and the pathogenesis is still not clear.By using the proteomics and bioinformatic in recent years, many protein markers related with COPD development have been excavated from the patients′ body fluids, bronchoalveolar lavage fluid, induced sputum, exhaled air condensate, lung tissue and other specimens, which may provide new strategy and new tools for molecular pathogenesis, diagnosis and differential diagnosis, prognosis and intervention of this disease.In this review article, research progress of proteomic COPD is briefly described, based on samples obtained from different human sources. Key words: Pulmonary disease, chronic obstructive; Biological markers; Proteomics; Diagnosis; Prognosis