IDDF2019-ABS-0044 Utility of intestinal tissue biopsy xpert-Mtb/Rif in evaluation of patients with ileo-caecal ulcers

<h3>Background</h3> Ileo-cecal ulcers could result from a number of conditions including intestinal tuberculosis and Crohn’s disease. We report the use of GeneXpert Mtb/Rif in the diagnosis of ITB in patients with ileo-cecal ulcers. <h3>Methods</h3> One year retrospective study involving patients with ileo-cecal ulcers who underwent GeneXpert Mtb/Rif from the intestinal biopsies taken from ulcers. The results of the test were compared with the final diagnosis. We divided the patients into two groups: those with a final diagnosis of ITB and those with a final diagnosis other than ITB (OTH). <h3>Results</h3> Of the 40 patients with ileo-cecal ulcers included, 23 (57.5%) were females and the mean age was 32.92±12.78 years. Abdominal pain was present in 33 (88.5%) patients and diarrhea in 12 (30%). Out of 40 patients, 25 had ITB and 15 patients were in the OTH group. The sensitivity, specificity, negative predictive value, the positive predictive value and accuracy of GeneXpert-Mtb/Rif for diagnosis of ITB was 32% (CI: 14.95–53.50%), 100% (78.2–100), 46.88% (40.27–53.59%), 100 &amp; 57.50 (40.89–72.89)% respectively. <h3>Conclusions</h3> A positive GeneXpert-Mtb/Rif is helpful in the diagnosis of ITB but the sensitivity is low.