TB Research

Isoniazid-induced encephalopathy in an end-stage renal disease patient - A case report and literature review.

Julie Low, Koh Wei Wong

PubMed · 2019-12

Abstract

Patients with end stage renal disease have higher risk of tuberculosis due to lower cell-mediated immunity. Standard regime of anti-tuberculosis contains isoniazid where neurological side effects such as seizure and encephalopathy have been documented. We present a case of isoniazid-induced encephalopathy in a haemodialysis patient. A literature review on isoniazid-induced encephalopathy was done. Recognition of this condition is important as it is reversible with cessation of isoniazid and institution of high dose pyridoxine.

MeSH terms

  • Medicine
  • Isoniazid
  • Encephalopathy
  • Pyridoxine
  • Tuberculosis
  • Disease
  • End stage renal disease
  • Pediatrics
  • Intensive care medicine
  • Internal medicine