The Effects Of Respiratory Viruses on The Acute Pulmonary Exacerbations In Cystic Fibrosis Patients

The impacts of respiratory viruses in pulmonary exacerbations of CF patientsis not fully understood <b>Method:</b> Prospective longitudinal study, 50 CF 6-18 who produce sputum and PEx (2016-2018). Sputum viral respiratory PCR panel, aerobic and fungal culture. Blood count, sedimentation rates and serum C-reactive protein levels were measured and standard spirometry and radiological severity score performed. Additional nasopharyngeal (NP) swab was taken for respiratory virus assessment if clinician considers it necessary. <b>Results:</b> 48.9% sputum samples virus-positive. Human rhinovirus was the most common pathogen (23,4%). Influenza A and B detected in 10% by sputum and 18% by combination of swab and sputum. There was no difference in term of demographics, comorbidities, FEV1 at PEx, radiograph parameters and score, influenza vaccination rates, previous FEV1 and day of antibiotics. In multivariate analysis saturation &lt;93 and dyspnea can predict viral exacerbations. In patient with influenza positivity nose flow and sedimentation rate significantly higher. Influenza positive patients more likely to had severe exacerbation and hospitalization. İnfluenza vaccination rates were 50%. Half of patients with influenza were vaccinated in that year. Sputum and swab results were discordant. <b>Conclusion:</b> Respiratory viruses are common in CF PEx In precense of acute hypoxia and dyspnea viral coexistence should be suspected At influenza season, if patients have nasal discharge and high sedimentation rate, influenza should suspected even if patient vaccinated for influenza By combination of sputum and swab viral detection rate increases