TB Research

Reversible Color Blindness due to Ethambutol in a Pediatric Patient with Pulmonary Tuberculosis

Tuğba Şişmanlar Eyüboğlu, Sevgi Yaşar Durmuş, Selin Şahin Karamert, Ayşe Kaman, Türkan Aydın Teke, Fatma Nur Öz, Gönül Tanır

Abstract

<b>Objective:</b> Ethambutol is an anti-tuberculosis drug which is commonly used in the first line treatment of tuberculosis. It has ophthalmological side effects but it was reported to be safe in children. Herein, we present a boy patient with pulmonary tuberculosis and reversible color blindness due to ethambutol. <b>Case Presentation:</b> A 14 year-old boy admitted with chronic cough and sputum. He had weight loss. Nodular infiltration and bronchiectasis were present both in chest x-ray and chest tomography. ARB was positive in sputum and he was dignosed as pulmonary tuberculosis. Isoniasid (15 mg/kg/d), rifampisin (15 mg/kg/d), ethambutol (15 mg/kg/d) and yyranizamide (30 mg/kg/d) were started as initial treatment. On 7th week of the treatment he had visual complaints. In the ophthalmological examination severe red-green color blindness was detected. Ethambutol was stopped immediately and ophthalmological examination returned to normal after two months <b>Discussion:</b> Although it was reported that optic toxicity of ethambutol is very rare in patients who had lower dose of ethambutol treatment, it should be kept in mind in patient who received ethambutol treatment. Regular ophtalmological examination and questionning the patients in terms of ophtalmological complaints in every visit during tuberculosis treatment is very important for early detection of ophtalmological side effects of ethambutol.

MeSH terms

  • Ethambutol
  • Medicine
  • Tuberculosis
  • Sputum
  • Surgery
  • Bronchiectasis
  • Sputum culture
  • Isoniazid